During a blizzard in 1964, Dr. David Henry delivers his son Paul with the help of nurse Caroline. But when Henry realizes his wife is also carrying a girl with Down syndrome, he hands the second child over to Caroline without his wife's knowledge. Henry's fateful decision yields grave consequences for his family over the next 20 years.

Calvin Campbell is a former professional baseball player sent to an early retirement due to his panic attacks at the plate. Even though he had all the talent for the big leagues, he struggles with the curveballs life has thrown him. Today, he mindlessly sleepwalks through his days and the challenge of raising his teenager daughter. His life is in a slow downward spiral when it is suddenly awakened and invigorated by the most unlikely person – Produce, a young-man with Down syndrome who works at the local grocery store.

A man in his mid-20s, still living at home with his mother and stepfather, puts all his eggs in one basket: the girl who works at his local coffee shop. The problem is, she has a serious boyfriend. As they become closer, the line between friendship and intimacy is blurred, and the situation forces both to examine where they are in their lives.

Rachel is a 35-year-old school teacher who has no man in her life and lives with her mother. When a man from the big city returns and asks her out, she begins to have to make decisions about her life and where she wants it to go.

After months of living a solitary existence, Lenny, 34, picks up his kids from school. Every year he spends a couple of weeks with his sons Sage, 9, and Frey, 7. Lenny hosts his kids within a midtown studio apartment in New York. During these two weeks, he must figure out if he wants to act as their father or be their friend. Ultimately, their trip upstate results in complete lawlessness taking over their lives.

Up-and-coming sports reporter rescues a homeless man ("Champ") only to discover that he is, in fact, a boxing legend believed to have passed away. What begins as an opportunity to resurrect Champ's story and escape the shadow of his father's success becomes a personal journey as the ambitious reporter reexamines his own life and his relationship with his family.

The story of August Pullman – a boy with facial differences – who enters fifth grade, attending a mainstream elementary school for the first time.

Jamie Fitzpatrick and Nona Alberts are two women from opposites sides of the social and economic track, but they have one thing in common: a mission to fix their community's broken school and ensure a bright future for their children. The two women refuse to let any obstacles stand in their way as they battle a bureaucracy that's hopelessly mired in traditional thinking, and they seek to re-energize a faculty that has lost its passion for teaching.

Four siblings' lives change drastically when their ailing mother takes a turn for the worse over the holiday season.

Maggie has had four children, by four different fathers, removed by social services because of a previous violent relationship. When she meets Jorge, a gentle Latin American refugee, she gradually sees her chance for happiness, but her history still haunts her.

Evangelist Carlton Pearson is ostracized by his church for preaching that there is no Hell.

When Ruth Matthews's husband is killed in a fall at an archaeological dig, her daughter Sally handles her father's death in a very odd manner. As Sally's condition worsens, Ruth takes her to see Jake, an expert in childhood autism. Jake attempts to bring Sally out of her mental disarray through traditional therapy methods, but Ruth takes a different route. She risks her own sanity by attempting to enter her daughter's mind and make sense of the seemingly bizarre things that Sally does, including building a wondrous house of cards

A widow with three children hires a handyman to fix her house during a major storm. When not doing home repairs, he shares his philosophy of believing in the power of the universe to deliver what we want.

Struggling to provide her daughters with a safe, happy home, Sandra decides to build one - from scratch. Using all her ingenuity to make her ambitious dream a reality, Sandra draws together a community to lend a helping hand to build her house and ultimately recover her own sense of self.

An optimistic, talented teen clings to a huge secret: she's homeless and living on a school bus. When tragedy strikes, can she learn to accept a helping hand?

A suicidal young man is committed to a Dublin psychiatric hospital where he meets new friends who greatly influence his life.

Handsome but backward gardener Tim Melville has a new woman in his life. She is Mary, his widowed employer, a woman who had given up on love until she had found Tim. At first they are friends. But soon they become lovers, as Mary, drawn to Tim's innocence and magnetism, begins to teach him all about life - and love.

Two kids, Dylan and Kylie, run away from home on Christmas Day and spend a night of magic and terror on the streets of inner-city Dublin.

A chronicle of three weeks in the lives of several high school teachers, administrators and students through the eyes of substitute teacher, Henry Barthes. Henry roams from school to school, imparting modes of knowledge, but never staying long enough to form any semblance of sentient attachment.

Three friends begin a dangerous three-way relationship that spirals out of control, leading to dire consequences that haunt them ten years later.