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Zach Riley is a psychiatrist, who leaves a job at a prestigious university, to take up a job at the privately run mental institution, Millwood. What he doesn't reveal at the time of his appointment is that this was the very place where his novelist father, T.L. Pierson, spent many years of his life.

Dr. Alan Stone breaks new ground for treatment of the mentally ill through an experiment on three paranoid schizophrenic patients who believe they are Jesus Christ.

A young man who was sentenced to 7 years in prison for robbing a post office ends up spending 30 years in solitary confinement. During this time, his own personality is supplanted by his alter ego, Charles Bronson.

A petty criminal fakes insanity to serve his sentence in a mental ward rather than prison. He soon finds himself as a leader to the other patients—and an enemy to the cruel, domineering nurse who runs the ward.

A young Western woman is recruited by the Mossad to go undercover in Tehran where she becomes entangled in a complex triangle with her handler and her subject.

Matthew, a young schizophrenic, finds himself out on the street when a slumlord tears down his apartment building. Soon, he finds himself in even more dire straits, when he is threatened by Little Leroy, a thug who is one of the tough denizens of the Fort Washington Shelter for Men. He reaches out to Jerry, a streetwise combat veteran, who takes Matthew under his wing as a son. The relationship between these two men grows as they attempt to conquer the numbing isolation of homelessness.

A psychic's ominous reading sends a man into a tailspin.

At the end of WWII, Jimmy Picard, a Native American Blackfoot who fought in France, suffers from unexplainable symptoms and is admitted to a military hospital. When doctors suspect schizophrenia, an eccentric psychoanalyst takes up the case and starts a conversation with the veteran.

A troubled young woman becomes obsessed with her mysterious new neighbor, who bears a striking resemblance to the girl's dead mother.

A soldier recounts his relationship with a famous political prisoner attempting to overthrow their country's authoritarian government.

A woman is released from prison after serving a sentence for a violent crime and re-enters a society that refuses to forgive her past.

Mike, a rough sleeper in London, is trapped in a cycle of self-destruction as he attempts to turn his life around. Along the way, he encounters unexpected chances for a fresh start.

A homicide detective goes undercover as a patient to investigate a psychotherapist he believes is linked to a strange double murder. As his therapy sessions continue the line between fantasy and reality begins to blur.

Set in the changing world of the late 1960s, Susanna Kaysen's prescribed "short rest" from a psychiatrist she had met only once becomes a strange, unknown journey into Alice's Wonderland, where she struggles with the thin line between normal and crazy. Susanna soon realizes how hard it is to get out once she has been committed, and she ultimately has to choose between the world of people who belong inside or the difficult world of reality outside.

Two young men are seriously affected by the Vietnam War. One of them has always been obsessed with birds - but now believes he really is a bird, and has been sent to a mental hospital. Can his friend help him pull through?

On the outside, Helen has it all – a loving family and a successful career – but when her suppressed mental illness resurfaces, the world crumbles around her. Crippled by depression, Helen finds solace through her friendship with Mathilda, a kindred spirit struggling with bipolar disorder.

Living in rural Texas is a dysfunctional family: an abusive dad, a Vietnam vet with a war wound that's left him impotent; a compliant wife and a son of about 20, two small sons who look a lot like their brother. The dad harbors a secret, and he goes to murderous lengths to keep it hidden. The young man, Jimmy, who has suspicions, but little comes out until a Yankee woman comes to town.

A disturbed and institutionalized 16-year-old girl struggles between fantasy and reality.

Will arrives for his last year at Military Academy, in the Deep South USA, in the 1960's. A black student, Pearce, has been accepted, for the first time and Will is asked to keep an eye out for the inevitable racism. The racists come in the form of The Ten, a secret group of the elite students. They want Pearce to leave on his own free will, but are prepared to torture him to make it 'his free will'. Will is forced to help Pearce and he is prepared to risk his own career to do so.

Two law school friends find themselves at odds when one becomes a Justice Department lawyer and the other goes into politics.