This time the "amici" (friends) are just four: Necchi, Meandri, Mascetti and Sassaroli. Nevertheless they are older they still love to spend their time mainly organizing irresistible jokes to everyone in every kind of situation. Mascetti is hospitalized in a geriatric clinic. Of course the place become immediately the main stage for all their jokes. After some jokes they decided to place an ultimate incredible and farcical joke to the clinic guests.

After a night of drinking, Adam Hutcherson stumbles out of the closet to his three straight buddies. A disruption to their dynamic which they now must try and overcome through alcohol, Tinder dates and forgiveness.

Advertising executive Nick Beame learns that his wife is sleeping with his employer. In a state of despair, he encounters a bumbling thief whose attempted carjacking goes awry when Nick takes him on an involuntary joyride. Soon the betrayed businessman and the incompetent crook strike up a partnership and develop a robbery-revenge scheme. But it turns out that some other criminals in the area don't appreciate the competition.

Mexican aviation exec Renato is shocked to learn that he has an American half-brother he never knew about: free-spirited Asher. They are forced on a road trip together, tracing the path their father took from Mexico to the U.S.

After college graduation, Grover's girlfriend Jane tells him she's moving to Prague to study writing. Grover declines to accompany her, deciding instead to move in with several friends, all of whom can't quite work up the inertia to escape their university's pull. Nobody wants to make any big decisions that would radically alter his life, yet none of them wants to end up like Chet, the professional student who tends bar and is in his tenth year of university studies.

Restless and ready for an adventure, four suburban bikers leave the safety of their subdivision and head out on the open road. But complications ensue when they cross paths with an intimidating band of New Mexico bikers known as the Del Fuegos.

Ana meets Rafa in a chance encounter and they embark on a road trip to try and save him from bankruptcy, or worse.

The four old friends meet on the grave of the fifth of them, Perozzi, who died at the end of the first episode. Time has passed but they are still up for adventures and cruel jokes, and while they recall the one they created together with the late friend, new ones are on their way, starting right there at the cemetery.

After their high school basketball coach passes away, five good friends and former teammates reunite for a Fourth of July holiday weekend.

A bumbling tramp desires to build a home with a young woman, yet is thwarted time and time again by his lack of experience and habit of being in the wrong place at the wrong time..

Friends Aldo, Giovanni, and Giacomo cross Italy from north to south for Giacomo's wedding: the father of the bride, a despotic magnate who is both their boss and father-in-law—since Aldo and Giovanni have also married into the family not for love but for money, a fate now awaiting Giacomo—has entrusted them with a priceless piece of modern art, one that looks just like a rather unremarkable wooden leg.

Two street basketball hustlers try to con each other, then team up for a bigger score.

When recently single Steven moves into his new apartment, cable guy Chip comes to hook him up—and doesn't let go. Initially, Chip is just overzealous in his desire to be Steven's pal, but when Steven tries to end the 'friendship', Chip shows his dark side. He begins stalking Steven, who's left to fend for himself because no one else can believe Chip's capable of such behaviour.

Frank Drebin is persuaded out of retirement to go undercover in a state prison. There he has to find out what top terrorist, Rocco, has planned for when he escapes. Adding to his problems, Frank's wife, Jane, is desperate for a baby.

As his wedding day approaches, Ben heads to Miami with his soon-to-be brother-in-law James to bring down a drug dealer who's supplying the dealers of Atlanta with product.

Will is looking for an escape from his family when he encounters Lee, the school bully. Armed with a video camera and a copy of Rambo, Lee plans to make his own action-packed video epic.

Detective Guy Johnson's client, Willie Heywood, is framed for murder. While Guy hides him so he can catch the real killer, both of them are nabbed by the police, tried, convicted and sentenced to jail: Guy for a year with Willie to be executed. On the way to jail, Guy comes across a clue and escapes from the police.

On his first day after being released from jail for 14 armed bank robberies, Lucas finds himself caught up in someone else's robbery. Perry has decided to hold up the local bank to raise money so that he can keep his daughter, Meg, and get her the treatment she needs. Dugan, a detective, assumes Lucas helped plan the robbery, and hence Lucas, Perry and Meg become three fugitives.

When free-spirited Rickey suddenly reappears in father-to-be Glenn’s life, the two former best friends embark on a spontaneous road trip from LA to Sacramento.

After Doug picks up hitchhiking Rosco with his truck, they are mistaken for two bank robbers by the traffic police. They manage to escape only to be confused for two secret agents while trying to take a flight at the airport.