Sam and Tusker, partners of 20 years, are traveling across England in their old RV visiting friends, family and places from their past. Since Tusker was diagnosed with early-onset dementia two years ago, their time together is the most important thing they have. As the trip progresses, however, their ideas for the future clash, secrets come out, and their love for each other is tested as never before. Ultimately, they must confront the question of what it means to love one another in the face of Tusker’s illness.

Richard is assigned public service after crashing his homemade aircraft, leading him to meet Jane, a young woman dying of motor neuron disease. Jane wishes to be de-flowered before her death; Richard declines, struggling to maintain his relationship with his girlfriend, but offers to help pay for a gigolo to do the deed.

Stand-up comedian Max Bernal lives with his father Stan while struggling to co-parent his autistic son Ezra with his ex-wife. When forced to confront difficult decisions about their son's future, Max and Ezra embark on a cross-country road trip that has a transcendent impact on both their lives.

A wheelchair-bound singer and her best friend embark on a roadtrip to Memphis.

Ana meets Rafa in a chance encounter and they embark on a road trip to try and save him from bankruptcy, or worse.

A passenger on a cruise ship develops an irresistible infatuation with an eccentric paraplegic's wife.

A young man with Tourette's Syndrome embarks on a road trip with his recently-deceased mother's ashes.

Lou Clark, a directionless 26-year-old from the English countryside, takes a job at the local castle as a caregiver and companion to a wealthy young banker, Will Traynor. Wheelchair-bound from an accident two years prior, the once adventurous Will has all but given up — that is until Lou determines to show him that life is worth living.

After a confrontation with one of his idols dashes his dreams of studying public speaking in college, Richard Pimentel joins the Army and ships off to Vietnam. During his service, Richard loses nearly all of his hearing. Joining a new circle of friends, including a man with cerebral palsy and an alcoholic war veteran, Richard discovers his gift for motivational speaking and becomes an advocate for people with disabilities.

After learning that his terminally ill wife has six months to live, a man welcomes the support of his best friend who moves into their home to help out.

When car dealer Charlie Babbitt learns that his estranged father has died, he returns home to Cincinnati, where he discovers that he has a savant older brother named Raymond and that his father's $3 million fortune is being left to the mental institution in which Raymond lives. Motivated by his father's money, Charlie checks Raymond out of the facility in order to return with him to Los Angeles. The brothers' cross-country trip ends up changing both their lives.

A mentally ill young woman finds her love in an eccentric man who models himself after Buster Keaton.

Self-described misanthrope Elle Reid has her protective bubble burst when her 18-year-old granddaughter, Sage, shows up needing help. The two of them go on a day-long journey that causes Elle to come to terms with her past and Sage to confront her future.

When Will Ferrell's good friend Harper comes out as a trans woman, they take a road trip to bond and reintroduce Harper to the country as her true self.

Following the death of their friend, two girls in their late twenties embark on a road trip to spread his ashes. Seph and Alex take turns driving. Dan is in the glove compartment, in tupperware, decreasing in volume as the trip progresses.

Matt Ryder is convinced to drive his estranged and dying father Benjamin Ryder cross country to deliver four old rolls of Kodachrome film to the last lab in the world that can develop them before it shuts down for good. Along with Ben's nurse Zooey, the three navigate a world changing from analogue to digital while trying to put the past behind them.

After an accident leaves her a paraplegic, a former soap opera star struggles to recover both emotionally and mentally, until she meets her newest nurse, who has struggles of her own.

A love story between two savants with Asperger's syndrome, a kind of autism, whose conditions sabotage their budding relationship.

Precocious young Harriet and her older sister Gwen live at their mother's motel in small-town New Hampshire. Harriet dreams of a life beyond her inattentive family and the stultifying town. A mentally disabled man named Ricky comes to stay at the motel, and Harriet finds him kinder and more interesting than anyone she has ever met. After tragedy strikes, Harriet and Ricky cling to each other ever more tightly.

A runaway couple go on an unforgettable journey from Boston to Key West, recapturing their passion for life and their love for each other on a road trip that provides revelation and surprise right up to the very end.