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Three stories about the world of opioids collide: a drug trafficker arranges a multi-cartel Fentanyl smuggling operation between Canada and the U.S., an architect recovering from an OxyContin addiction tracks down the truth behind her son's involvement with narcotics, and a university professor battles unexpected revelations about his research employer, a drug company with deep government influence bringing a new "non-addictive" painkiller to market.

Undercover cop Jim Raynor is a seasoned veteran. His partner, Kristen Cates, is lacking in experience, but he thinks she's tough enough to work his next case with him: a deep cover assignment to bring down the notoriously hard-to-capture drug lord Gaines. While their relationship turns romantic during the assignment, they also turn into junkies, and will have to battle their own addictions if they want to bring down Gaines once and for all.

In this true story, Veronica Guerin is an investigative reporter for an Irish newspaper. As the drug trade begins to bleed into the mainstream, Guerin decides to take on and expose those responsible. Beginning at the bottom with addicts, Guerin then gets in touch with John Traynor, a paranoid informant. Not without some prodding, Traynor leads her to John Gilligan, the ruthless head of the operation, who does not take kindly to Guerin's nosing.

Black police officer Russell Stevens applies for a special anti-drug squad which targets the highest boss of cocaine delivery to LA—the Colombian foreign minister's nephew. Russell works his way up from the bottom undercover, until he reaches the boss.

When a seemingly straight-forward drug deal goes awry, XXXX has to break his die-hard rules and turn up the heat, not only to outwit the old regime and come out on top, but to save his own skin...

Loosely based on the criminal career of Frank Lucas, a gangster from La Grange, North Carolina, who smuggled heroin into the United States on American service planes returning from the Vietnam War, before being detained by a task force led by Newark Detective Richie Roberts.

College student Jake Lo is pursued by smugglers, mobsters and crooked federal agents after he witnesses a murder by a Mafia kingpin.

Based on true events. A disgraced police detective seeking redemption goes undercover to expose a violent crime syndicate. But as he sinks deeper into the mob, the price for absolution may be higher than he can afford.

Drug lord Dwayne Gittens rules Cincinnati with an iron fist. No wonder he's known as "God" on the streets. Determined to break Gittens' stranglehold on the city is undercover cop Jeffrey Cole. But as Cole takes on an assumed identity to penetrate Gittens' criminal empire, he makes a disturbing discovery -- he kind of likes being a gangster.

Held in an L.A. interrogation room, Verbal Kint attempts to convince the feds that a mythic crime lord, Keyser Soze, not only exists, but was also responsible for drawing him and his four partners into a multi-million dollar heist that ended with an explosion in San Pedro harbor – leaving few survivors. Verbal lures his interrogators with an incredible story of the crime lord's almost supernatural prowess.

Strike is a young city drug pusher under the tutelage of drug lord Rodney Little. When a night manager at a fast-food restaurant is found with four bullets in his body, Strike’s older brother turns himself in as the killer. Detective Rocco Klein doesn’t buy the story, however, setting out to find the truth, and it seems that all the fingers point toward Strike & Rodney.

The story of Richard Wershe Jr., a teenager who became an undercover informant for the police during the 1980s, and was ultimately arrested for drug trafficking and sentenced to life in prison.

After a heist, four criminals lay low in a remote safehouse, waiting for orders. As paranoia builds, one thing becomes clear — the real threat may not be outside, but among them.

Jackie Brown is a flight attendant who gets caught in the middle of smuggling cash into the country for her gunrunner boss. When the cops try to use Jackie to get to her boss, she hatches a plan — with help from a bail bondsman — to keep the money for herself.

A police officer who while responding to a violent hostage call, kills the African American suspect only to later learn of his innocence. Sensing this was a set-up, and facing repercussions, he must track down the person responsible while examining his own accountability and the ingrained racism which brought him to this point.

Reclusive and controversial author Bruce Cogburn is drawn out of hiding by an obsessive fan, forcing the novelist to confront a past that he thought he could escape, and to account for events set in motion by his bestseller decades earlier. Cogburn's search for who is behind the manipulation and mental torment he encounters leads to an emotional roller-coaster ride full of fear and danger, where things are not always as clear as they seem to be, and where past deeds can have dire consequences.

A boy named George Jung grows up in a struggling family in the 1950's. His mother nags at her husband as he is trying to make a living for the family. It is finally revealed that George's father cannot make a living and the family goes bankrupt. George does not want the same thing to happen to him, and his friend Tuna, in the 1960's, suggests that he deal marijuana. He is a big hit in California in the 1960's, yet he goes to jail, where he finds out about the wonders of cocaine. As a result, when released, he gets rich by bringing cocaine to America. However, he soon pays the price.

A young street hustler attempts to escape the rigors and temptations of the ghetto in a quest for a better life.

In New York, racist Capt. Stanley White becomes obsessed with destroying a Chinese-American drug ring run by Joey Tai, an up-and-coming young gangster as ambitious as he is ruthless. While pursuing an unauthorized investigation, White grows increasingly willing to violate police protocol, resorting to progressively violent measures -- even as his concerned wife, Connie, and his superiors beg him to consider the consequences of his actions.

FBI informant Jim Hoffman lures troubled automobile magnate John DeLorean to an undercover sting for cocaine trafficking.