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Seen-it-all New York detective Frank Keller is unsettled - he has done twenty years on the force and could retire, and he hasn't come to terms with his wife leaving him for a colleague. Joining up with an officer from another part of town to investigate a series of murders linked by the lonely hearts columns he finds he is getting seriously and possibly dangerously involved with Helen, one of the main suspects.

Rachel Watson, devastated by her recent divorce, spends her daily commute fantasizing about the seemingly perfect couple who live in a house that her train passes every day, until one morning she sees something shocking happen there and becomes entangled in the mystery that unfolds.

Lincoln Rhyme was the department's top homicide detective and leading expert in criminal forensics until an injury left him paralyzed, depressed, and incapable of working. But when a gruesome murder in Manhattan leaves detectives baffled, they call on Rhyme to help solve the mystery. Amelia Donaghy, a rookie cop whose quick thinking preserved a gruesome murder scene, is enlisted by Rhyme to be his on-the-scene forensics expert. With Amelia reluctantly acting as Rhyme's able-bodied go-between, the pair piece together cryptic clues the killer leaves behind at the scene of the crime, hoping to catch the grisly serial killer.

A young paramedic is paired with a seasoned partner on the night shift in New York revealing a city in crisis. Discovering the chaos firsthand, he is tested with the ethical ambiguity that can be the difference between life and death.

Nick Hume is a mild-mannered executive with a perfect life, until one gruesome night he witnesses something that changes him forever. Transformed by grief, Hume eventually comes to the disturbing conclusion that no length is too great when protecting his family.

Anna suffers from agoraphobia so crippling that when a trio of criminals break into her house, she cannot bring herself to flee. But what the intruders don't realize is that agoraphobia is not her only psychosis.

Private investigator Matthew Scudder is hired by a drug kingpin to find out who kidnapped and murdered his wife.

Once called "Father Frank" for his efforts to rescue lives, Frank Pierce sees the ghosts of those he failed to save around every turn. He has tried everything he can to get fired, calling in sick, delaying taking calls where he might have to face one more victim he couldn't help, yet cannot quit the job on his own.

A young couple, Rosemary and Guy, moves into an infamous New York apartment building, known by frightening legends and mysterious events, with the purpose of starting a family.

While drying out on the West Coast, an alcoholic hit man befriends a tart-tongued woman who might just come in handy when it's time for him to return to Buffalo and settle some old scores.

A troubled Southern man talks to his suicidal sister's psychiatrist about their family history and falls in love with her (and New York City) in the process.

Still recovering from a heart transplant, a retired FBI profiler returns to service when his own blood analysis offers clues to the identity of a serial killer.

A struggling writer in the midst of a divorce befriends a retired serial killer who incidentally becomes his marriage counselor by day, and killing counselor for his next book by night.

Animal control officer Walter Sparrow becomes obsessed with a novel that he believes was written about him, as more and more similarities between himself and his literary alter ego seem to arise.

Four mental patients on a field trip in New York City must save their caring chaperone, who ends up being taken to a hospital in a coma after accidentally witnessing a murder, before the killers can find him and finish the job.

New York City writer Iris finds her comfortable, solitary life thrown into disarray after her closest friend and mentor bequeaths her a Great Dane named Apollo. The huge dog immediately creates practical problems for Iris, from furniture destruction to eviction notices, as well as more existential ones. Yet as Iris finds herself unexpectedly bonding with Apollo, she begins to come to terms with her past, and her own creative inner life.

A violent screenwriter and a female neighbor fall in love after she clears him of murder, but she begins to have second thoughts.

Claire Gregory, an upper class New York personality, witnesses a murder in a luxurious nightclub. Detective Mike Keegan, recently promoted, is assigned to protect her.

After a heist, four criminals lay low in a remote safehouse, waiting for orders. As paranoia builds, one thing becomes clear — the real threat may not be outside, but among them.

A young district attorney seeking to prove a case against a corrupt police detective encounters a former lover and her new protector, a crime boss who refuses to help him.