In their debut Austin City Limits appearance, influential superstars R.E.M. take the stage in support of their latest acclaimed record Accelerate.

R&B veteran Bettye LaVette sings songs from her critically-lauded album The Scene of the Crime, followed by legendary pianist Pinetop Perkins and his catalog of blues classics.

Acclaimed tunesmiths Lyle Lovett and his friends John Hiatt, Guy Clark and Joe Ely pool their talents for this special episode of Austin City Limits.

Wallflowers leader Jakob Dylan showcases tunes from his debut solo album Seeing Things, followed by songwriter/violinist Carrie Rodriguez performing songs from her latest album She Ain’t Me.

Kentucky’s indie rock heroes My Morning Jacket return to the ACL stage to showcase their latest acclaimed album Evil Urges.

Sharon Jones and the Dap-Kings burn up the stage with their modern take on classic soul and funk. Texas treasure Carolyn Wonderland follows with her incendiary blend of rock, blues and soul.

Singer/songwriter Aimee Mann debuts on the ACL stage with tunes from her latest album @#%&*! Smilers. Folk rockers Iron & Wine, showcasing their acclaimed The Sheperd’s Dog CD, follow.

Gnarls Barkley plays his unique combination of rhythm and blues, rock and progressive hip-hop. Next, Thievery Corporation introduces the audience to its eccentric world beats.

French/Spanish singer/songwriter and international star Manu Chao showcases politically-charged, danceable rock & roll from his album La Radiolina. Taped September 23, 2008:

British songwriting legend Nick Lowe surveys his 30-plus year catalog with classics and new tunes. Oscar-winning duo Glen Hansard & Marketa Irglova, AKA The Swell Season, performs cuts from the soundtrack of their movie Once.

Hard-rocking roots music storytellers Drive-By Truckers hit the stage in support of their album Brighter Than Creation's Dark. Dusty Texas troubadour Ryan Bingham follows with tunes from his latest record, Mescalito.

With the release of her greatest hits collection, Closer: The Best Of Sarah McLachlan, the multi-Grammy Winning singer, songwriter and activist makes her Austin City Limits debut.