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Australian author Bradley Trevor Greive is on the guest list.

Adam Scott is interviewed.

Kristen Bell talks up Season 3 of "House of Lies."

Idris Elba is on the guest list, along with panelists Nick Swardson, Sarah Colonna and Michael Rosenbaum.

Amy Adams is interviewed. On the panel: Moshe Kasher; Fortune Feimster; Dov Davidoff.

An interview with Zosia Mamet. Also: Heather McDonald, Julian McCullough and Gary Valentine are on the panel.

Taylor Schilling is interviewed. On the panel: Giulia Rozzi; Josh Wolf; Loni Love.

John Leguizamo promotes his movie "Ride Along." On the panel: Leah Remini; Mary McCormack; Whitney Cummings.

Kendall and Kylie Jenner promote the Season 9 premiere of "Keeping Up With the Kardashians."

Heather Graham is interviewed. On the panel: John Caparulo, Claire Titelman and Ross Mathews.

Emmy Rossum talks about Season 3 of "Shameless." Ben Gleib is on the panel, along with April Richardson and Ryan Stout.

David Spade ("The Spoils of Babylon") is on the guest list.

Gabourey Sidibe talks about her role on "American Horror Story: Coven." On the panel: Kerri Kenney-Silver; Natasha Leggero; Bobby Lee.

Timothy Olyphant chats about Season 5 of "Justified." On the panel: Michael Yo; Jamie Lee; Ross Mathews.

Andy Samberg is interviewed. On the panel: Moshe Kasher; Loni Love; and Gary Valentine.

Gabrielle Union is interviewed. On the panel: Ron G; Heather McDonald; Ian Karmel.

Emma Roberts is interviewed. On the panel: Chris Franjola; Sarah Colonna; Dustin Ybarra.

Vanessa Hudgens is interviewed. On the panel: John Caparulo; Fortune Feimster; Julian McCullough.

Michelle Monaghan ("True Detective") is on the guest list. Panelists: Natasha Leggero; Sarah Tiana; Whitney Cummings.

Mariska Hargitay is interviewed. On the panel: Jo Koy; Janine Brito; Ross Mathews.

Emma Kenney ("Shameless") is on the guest list. Panelists: Brody Stevens; Jen Kirkman; Kurt Braunohler.

Director McG ("3 Days to Kill"). Also: Jeff Wild, Cameron Esposito and Matt Braunger are on the panel.

Sharon Osbourne.

Chelsea celebrates Fashion Week. On the panel: Eliza Skinner; Lovi Love; Ryan Stout.

Alison Brie is interviewed. On the panel: Kerri Kenney-Silver; Liza Treyger; Josh Wolf.

Demi Lovato is interviewed.

Guest host Ross Mathews

Alex Pettyfer is on the guest list.

Scott Speedman talks about his role in the comedy "Barefoot."

Kurt Russell chats about starring in "The Art of the Steal." On the panel: Sarah Colonna, Moshe Kasher and Fortune Feimster.

Julianne Moore appears in support of her film "Non-Stop." On the panel: Jen Kirkman, Beth Stelling and Jo Koy.

Sarah Paulson is interviewed. On the panel: John Caparulo, Morgan Murphy and April Richardson.

Figure skaters Tara Lipinski and Johnny Weir are interviewed. Also: Dov Davidoff, Whitney Cummings and Tone Bell are on the panel.

Michelle Dockery of "Downton Abbey" is interviewed. On the panel: Kurt Braunohler, Fortune Feimster and Dustin Ybarra.

Cameron Diaz chats about writing "The Body Book."

Guest host Gabourey Sidibe

Guest host Khloe Kardashian

Guest host Mary McCormack

Minnie Driver is interviewed.

Chelsea chats with Emily Mortimer about the HBO comedy series "Doll & Em."

Adam Levine is interviewed.

A pastor thinks the movie "Frozen" has a gay agenda, Steven Tyler is allegedly dating his younger assistant, passengers on a Carnival Cruise want lifetime retribution, and from "Tyler Perry's Single Moms Club" Tyler Perry is here.

L.A had an earth quake this morning, the Malaysian airplane is still missing, Guinness beer pulls out of Saint Patrick's Day Parade, and from "Catch a Contractor" Adam Carolla is here.

The Pope refused to meet with Russell Crowe, Billy D Williams performed on "Dancing With The Stars", the couple from "Little Couple, Big World" are separating and from "Divergent" Theo James is here.

George Clooney has a new girlfriend, John Mayor is sueing Charlie Sheen's friend, The Duke porn star is getting rich, and from "Enlisted" Geoff Stults is here.

Johnny Weir and his husband split up, Selfies are causing a rise in plastic surgery, Is Malaysian Flight 370 somewhere off the coast of Australia, and snowboard champion Shaun White is here.

Drew Brees is interviewed.

Jayma Mays is interviewed.

Rapper Rick Ross is interviewed.

Bradley Trevor Greive stops by with cute baby animals.

Demián Bichir.

Mark Cuban is interviewed.

Don Cheadle is interviewed.

Mindy Kaling is interviewed.

Jamie Foxx is interviewed. Also: John Caparulo, Beth Stelling and Brad Wollack appear on the panel.

Sebastian Stan chats about his role in "Captain America: The Winter Soldier." On the panel: Kerri Kenney-Silver; Dustin Ybarra; and Heather McDonald.

Nikolaj Coster-Waldau is interviewed.

Comedian Amy Schumer is interviewed. On the panel: April Richardson; Sarah Colonna; and Ross Mathews.

Marlon Wayans is interviewed.

Singer-songwriter Ellie Goulding is interviewed. On the panel: Bobby Lee; Whitney Cummings; and Julian McCullough.

Brooklyn Decker is interviewed. On the panel: Michael Yo; Loni Love; and Matt Braunger.

Guest host Khloe Kardashian

Guest host T.J. Miller

Guest hosts Loni Love

Guest host Mary McCormack

Giuliana and Bill Rancic are interviewed.

Hugh Dancy ("Hannibal") is on the guest list.

Helen Hunt discusses her role in the film "Decoding Annie Parker."

Neon Trees' frontman Tyler Glenn is interviewed.

Rapper 2 Chainz is interviewed. On the panel: Julian McCullough; Brad Wollack; and Liz Carey.

Jane Lynch is interviewed. On the panel: Chris Franjola; April Richardson; Gary Valentine.

Arianna Huffington is interviewed. On the panel: Jen Kirkman; Kevin Christy; and Josh Wolf.

Dave Franco is interviewed. On the panel: Nick Thune; Ian Karmel; Heather McDonald.

Connie Britton is interviewed.

Sandra Oh is interviewed.

"Nurse Jackie" star Edie Falco is on the guest list.

Evan Peters is on the guest list. On the panel: Ron Funches, Sarah Tiana and Brad Wollack.

Australian rapper Iggy Azalea is interviewed. On the panel: Michael Yo; Bobby Lee; and Jo Koy.

Charlize Theron is interviewed.

Drew Barrymore and Adam Sandler are interviewed.

Joel McHale is interviewed.

Terry Crews is interviewed.

Sarah Silverman.

Lea Michele is interviewed.

Kelly Osbourne is on the guest list.

Giovanni Ribisi is interviewed. On the panel: Jeff Wild, Natasha Leggero and Josh Wolf.

Singer Austin Mahone is interviewed.

Colin Hanks is interviewed.

Lena Headey is interviewed.

Chelsea chats with Channing Tatum.

Jenny Slate chats about her movie "Obvious Child." On the panel: Liza Treyger; Jen Kirkman; Julian McCullough.

Rob Riggle is interviewed. On the panel: Moshe Kasher; Fortune Feimster; and Bobby Lee.

Jason Biggs ("Orange Is the New Black") is interviewed.

The cast of the Lifetime reality series "Little Women: LA" are on the guest list. Panelists include Greg Fitzsimmons, Sarah Tiana and Julian McCullough.

Laverne Cox ("Orange Is the New Black"). On the panel: Chris Franjola; Michael Yo; Josh Wolf.

Meagan Good appears in support of her movie "Think Like a Man Too." Also: Ben Gleib, Fortune Feimster and Ryan Stout are on the panel.

Kevin Hart is interviewed.

Jenna Dewan-Tatum chats about Season 2 of her Lifetime drama "Witches of East End."

Comedian Gabriel Iglesias is on the guest list.

Chris Rock is interviewed. On the panel: Brody Stevens; April Richardson; and Jo Koy.

Eric Bana is interviewed about his starring role in the thriller "Deliver Us From Evil."

Melissa McCarthy is interviewed. On the panel: Jeff Wild; Loni Love; Brad Wollack.

Susan Sarandon is interviewed. On the panel: Chris Franjola; Arden Myrin; Kurt Braunohler.

Bel Falcone is interviewed.

Model Chrissy Teigen is interviewed. On the panel: Josh Wolf; Loni Love; Gary Valentine.

Dane Cook is on the guest list. On the panel: Ben Gleib; Bobby Lee; Ross Mathews.

Cameron Diaz is interviewed. On the panel: Mary McCormack; Whitney Cummings; Julian McCullough.

Dean Norris ("Under the Dome") is interviewed.

Lela Loren is interviewed.

Frank Grillo, star of "The Purge: Anarchy," is interviewed.

Natasha Lyonne and Uzo Aduba, stars of "Orange Is the New Black," are interviewed.

John C. Reilly is interviewed.

Kelsey Grammer is interviewed.

Chris Pratt is interviewed.

Country music artist Jake Owen is on the guest list.

Ethan Hawke is interviewed.

NBA player Chandler Parsons.

Megan Fox is interviewed.

Liv Tyler ("The Leftovers") is interviewed.

In her opening monologue, host Chelsea Handler talks about what she did today at the studio on this the last day of the show, including the last communal shower she had in the Chelsea Lately shower facility. Chelsea and Chuy bring on her current stable of round table regulars. What Chelsea believes is going to be three of her closest celebrity friends, Mary McCormack - her best friend - Jennifer Aniston, and Sandra Bullock, providing a gracious send-off ends up being what they hope will be more useful for Chelsea's life. Chelsea's ex-lover 50 Cent and G-Unit perform their new single, "Watch Me". Chuy, via a prepared video, talks about what this show and Chelsea have meant to him. Miley Cyrus, in tribute to it being the last show, performs the pop classic, "It's Over". And many of Chelsea's musical friends, and some non-musical friends, help her serenade E!, to who she is grateful for the past seven years.