When billionaire Lance Durand's life is threatened, Alex Cross is called into action. But to find the killer, Cross must discover what someone would want to murder the man that feeds America.

A break in the investigation brings the team to Chicago following the man with the haunting grin from surveillance footage. While Kayla's personal mission encounters a tragedy.

After finding clues in the subway, Cross' team tracks the suspect to Texas, where they must work with Homeland Security to uncover another criminal enterprise.