When Spider-Man and Max Modell experiment on a sample of Venom symbiote, it escapes and unleashes a weapon of unknown purpose.

When Toddler Groot lands on Earth to deliver an urgent warning, Spider-Man must decode the message and keep him out of the evil clutches of both A.I.M. and Baron Mordo.

Symbiotes from space send an advanced hunting party to Earth to take out all of the superheroes; Spider-Man must team up with Marc Spector and Max Modell to save the planet.

Spider-Man discovers Norman Osborn is responsible for the Venom Symbiote's escape; Norman, aka the Dark Goblin, brings the Generations team to battle against Spider-Man.

When Spider-Man and his allies attempt to track down the missing and dangerous Lizard, they discover that Venom has returned to seek revenge on the earth.