Jimmy grapples with being an empty nester and feeling torn about Alice's major life choice. Paul faces fresh challenges with his Parkinson's.

The gang unites to support Paul during a health setback. Jimmy and Alice help Louis take a big step. Liz and Derek make a tough choice.

Gaby invites Jimmy to speak to her class. When Derek ends up in the hospital, Liz has issues with their son. Paul has an important realization.