Student Peter Parker is labeled a "bookworm" by his peers when he declines their offer of a triple-date in favor of viewing a radiology experiment.

On his first night at work at the Daily Bugle, Peter overhears talk of a fake medicine racket engineered by a rotund mobster called the Kingpin.

A twisted radiation specialist gains illicit dominion over Manhattan's new and only nuclear power plant and uses a special ray to lift Manhattan into the clouds.

Roy Robinson, star football player, campus ladies' man, son of a wealthy chemical industrialist, is envied by Peter, who decides to use his spider-power to play football and outperform Robinson.

Investigating the disappearance of banks, Spidey finds a hole that leads to a maze of underground tunnels, through which Spidey undertakes a perilous journey in search of the lost occupants of the submerged banks.

A baseball diamond and the spherical, baseball-sized Optimo Diamond at the Cosmopolitan Museum are connected in this episode.

Mugs Riley, evidently escaped from prison, has duped the Molemen into following him again.

Giant, mechanical beetles are used by Manta to capture and enslave the peace-loving inhabitants of an island to mine a valuable ore.

In ancient Egypt, one of the most aggressive of evil magicians, Kotep, the Scarlet Sorcerer, is defeated in battle with an opponent, and his own demons strike him with a cursing ball of fire that puts him in suspended animation, his mummified remains lasting through the passing centuries and becoming an exhibit at a New York university and the object of a professor's obsession.

A giant plant escapes from storage in a house belonging to Prof. Smithers, a missing scientist. Spidey goes through a portal (located in the scientist's home) to prehistoric times to find some defense against the plant and meets Smithers, who tells to him that two radium gems in an idol in a nearby city, if ingested by the plant in New York, will disintegrate it.

Pardo is a sorcerer with the ability to transform himself into a giant cat with hypnotic eyes. He lures top New York City’s citizens and officials to a theatre with the promise of a spectacular show, then releases his feline alter-ego's power upon the hapless audience, intending to divest them of their wealth and sap the souls out of their bodies.

Peter is an exchange student in South America, flying in a charter airplane with a Latin American professor in the Andes mountains. The airplane encounters a violent storm and crashes in a jungle, and Peter changes to Spider-Man to assist the professor and the airplane's two pilots in leaving the jungle and returning to civilization.

On Jameson's orders, Peter, and Daily Bugle pilot, Penny Jones travel by small-engine airplane to the Antarctic Ocean to track a fallen nose cone and crash-land on an island with a superstitious, brutish, native population.

At a coffee house, Peter meets Carol, a girl with whom he has much in common; he does not realize to what extent that they are alike until he, as Spider-Man, catches Carol in the act of robbing electrical equipment and finds that she has powers identical to his.

Clive, an unbalanced movie producer, is determined to avenge himself upon critics and audiences who spurned his claim that the darkest human emotions could be filmed and physically released from a theatre screen.

A giant Martian warrior, who throws lightning bolts, comes to Earth to rob the planet of its gold.

Dr. Irving Caldwell has devised a helmet capable of levitating its wearer and is kidnaped by a villainous scientist, Dr. Zap, who wants Caldwell's helmet to duplicate for his own evil use.

Two robbers dynamite a bank safe and abscond in their car with millions of stolen dollars.