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After he and his first wife separate, journalist David Sheff struggles to help their teenage son, who goes from experimenting with drugs to becoming devastatingly addicted to methamphetamine.

Heroin addict Mark Renton stumbles through bad ideas and sobriety attempts with his unreliable friends --Sick Boy, Begbie, Spud and Tommy. He also has an underage girlfriend, Diane, along for the ride. After cleaning up and moving from Edinburgh to London, Mark finds he can't escape the life he left behind as Begbie and Sick Boy come knocking.

The drug-induced utopias of four Coney Island residents are shattered when their addictions run deep.

A young drug-addled writer approaching the bottom of his descent submits to two months of agonizing detox at a treatment center in Minnesota.

A young heroin addict roams the streets of New York to panhandle and get her next fix, while her unstable boyfriend drifts in and out of her life at random.

A boy named George Jung grows up in a struggling family in the 1950's. His mother nags at her husband as he is trying to make a living for the family. It is finally revealed that George's father cannot make a living and the family goes bankrupt. George does not want the same thing to happen to him, and his friend Tuna, in the 1960's, suggests that he deal marijuana. He is a big hit in California in the 1960's, yet he goes to jail, where he finds out about the wonders of cocaine. As a result, when released, he gets rich by bringing cocaine to America. However, he soon pays the price.

When a seemingly straight-forward drug deal goes awry, XXXX has to break his die-hard rules and turn up the heat, not only to outwit the old regime and come out on top, but to save his own skin...

A high school basketball player’s life turns upside down after free-falling into the harrowing world of drug addiction.

A U.S Customs official uncovers a massive money laundering scheme involving Pablo Escobar.

A quiet, stoic man, lives a monk-like existence in self-imposed exile. When his estranged son is killed in a drug deal gone bad, he is left to look after a granddaughter he never knew existed, and he is forced back into a life he tried to put behind him.

Laney is an attractive, intelligent suburban wife and devoted mother of two adorable children. She has the perfect husband who plays basketball with the kids in the driveway, a pristine house, and a shiny SUV for carting the children to their next activity. However, just beneath the façade lie depression and disillusionment that send her careening into a secret world of reckless compulsion. Only very real danger will force her to face the painful root of her destructiveness and its crumbling effect on those she loves.

Private investigator Matthew Scudder is hired by a drug kingpin to find out who kidnapped and murdered his wife.

Nicolas Bannister, a rugged and solitary veteran living in a near-future Miami flooded by rising seas, is an expert in a dangerous occupation: he offers clients the chance to relive any memory they desire. His life changes when he meets a mysterious young woman named Mae. What begins as a simple matter of lost and found becomes a passionate love affair. But when a different client's memories implicate Mae in a series of violent crimes, Bannister must delve through the dark world of the past to uncover the truth about the woman he fell for.

John LeTour is a recovering drug user who suffers insomnia and still deals to a high-end New York clientele, even though he’s trying to move on from the business. John’s professional midlife crisis becomes something more acute — and dangerous — when he re-encounters an old flame while a string of seemingly drug-related murders rocks the city.

An urgent phone call pulls a Yale Law student back to his Ohio hometown, where he reflects on three generations of family history and his own future.

Stranded at a rest stop in the mountains during a blizzard, a recovering addict discovers a kidnapped child hidden in a car belonging to one of the people inside the building which sets her on a terrifying struggle to identify who among them is the kidnapper.

Free after years in prison, Carlito Brigante intends to give up his criminal ways, but it's not long before the ex-con is sucked back into the New York City underworld.

Utah and his girlfriend Opal, are drug addicts living on the streets in rural Ohio. After getting recruited by body broker Wood and offered treatment in Los Angeles, Wood takes Utah under his wing and introduces him to treatment center mogul Vin. Wood and Vin bring Utah in on their lucrative and illegal dealings, where saving lives comes second to the bottom line.

Juggling increasing career success and a growing heroin habit, a television comedy writer attempts to go down a path of improvement.

Frederick Fitzell is living his best life—until he starts having horrific visions of Cindy, a girl who vanished in high school. After reaching out to old friends with whom he used to take a mystery drug called Mercury, Fredrick realizes the only way to stop the visions lies deep within his own memories, so he embarks on a terrifying mental odyssey to learn the truth.