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After he and his first wife separate, journalist David Sheff struggles to help their teenage son, who goes from experimenting with drugs to becoming devastatingly addicted to methamphetamine.

Heroin addict Mark Renton stumbles through bad ideas and sobriety attempts with his unreliable friends --Sick Boy, Begbie, Spud and Tommy. He also has an underage girlfriend, Diane, along for the ride. After cleaning up and moving from Edinburgh to London, Mark finds he can't escape the life he left behind as Begbie and Sick Boy come knocking.

The drug-induced utopias of four Coney Island residents are shattered when their addictions run deep.

A young drug-addled writer approaching the bottom of his descent submits to two months of agonizing detox at a treatment center in Minnesota.

A young heroin addict roams the streets of New York to panhandle and get her next fix, while her unstable boyfriend drifts in and out of her life at random.

A boy named George Jung grows up in a struggling family in the 1950's. His mother nags at her husband as he is trying to make a living for the family. It is finally revealed that George's father cannot make a living and the family goes bankrupt. George does not want the same thing to happen to him, and his friend Tuna, in the 1960's, suggests that he deal marijuana. He is a big hit in California in the 1960's, yet he goes to jail, where he finds out about the wonders of cocaine. As a result, when released, he gets rich by bringing cocaine to America. However, he soon pays the price.

When a seemingly straight-forward drug deal goes awry, XXXX has to break his die-hard rules and turn up the heat, not only to outwit the old regime and come out on top, but to save his own skin...

In Los Angeles at the turn of the 1970s, drug-fueled detective Larry "Doc" Sportello investigates the disappearance of an ex-girlfriend.

A high school basketball player’s life turns upside down after free-falling into the harrowing world of drug addiction.

In 1950s Mexico City, William Lee, an American ex-pat in his late forties, leads a solitary life amidst a small American community. However, the arrival in town of Eugene Allerton, a young student, stirs William into finally establishing a meaningful connection with someone.

Ben Sanderson, an alcoholic Hollywood screenwriter who lost everything because of his drinking, arrives in Las Vegas to drink himself to death. There, he meets and forms an uneasy friendship and non-interference pact with prostitute Sera.

A U.S Customs official uncovers a massive money laundering scheme involving Pablo Escobar.

A quiet, stoic man, lives a monk-like existence in self-imposed exile. When his estranged son is killed in a drug deal gone bad, he is left to look after a granddaughter he never knew existed, and he is forced back into a life he tried to put behind him.

A poet falls in love with an art student, who gravitates to his bohemian lifestyle — and his love of heroin. Hooked as much on one another as they are on the drug, their relationship alternates between states of oblivion, self-destruction, and despair.

A burger-loving hit man, his philosophical partner, a drug-addled gangster's moll and a washed-up boxer converge in this sprawling, comedic crime caper. Their adventures unfurl in three stories that ingeniously trip back and forth in time.

A German student, Stefan, now finished with his studies, hitchhikes to Paris. There he meets a free-spirited American girl, Estelle, who he follows to Ibiza. The two begin a sad and dark path into heroin addiction.

Private investigator Matthew Scudder is hired by a drug kingpin to find out who kidnapped and murdered his wife.

Lured by their dreams of fame and fortune, three ambitious young women enter the world of show business and discover how easy it is to sink into a celebrity nightmare of ego, alcohol and pills — the beloved "dolls."

Los Angeles Police Department detective Russell Poole has spent years trying to solve his biggest case -- the murders of The Notorious B.I.G. and Tupac Shakur -- but after two decades, the investigation remains open. Jack Jackson, a reporter desperate to save his reputation and career, is determined to find out why. In search of the truth, the two team up and unravel a growing web of institutional corruption and lies.

Longtime alcoholic Don Birnam has been sober for ten days and appears to be over the worst... but his craving has just become more insidious. Evading a country weekend planned by his brother and girlfriend, he begins a four-day bender that just might be his last – one way or another.