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Zach Riley is a psychiatrist, who leaves a job at a prestigious university, to take up a job at the privately run mental institution, Millwood. What he doesn't reveal at the time of his appointment is that this was the very place where his novelist father, T.L. Pierson, spent many years of his life.

Set in the changing world of the late 1960s, Susanna Kaysen's prescribed "short rest" from a psychiatrist she had met only once becomes a strange, unknown journey into Alice's Wonderland, where she struggles with the thin line between normal and crazy. Susanna soon realizes how hard it is to get out once she has been committed, and she ultimately has to choose between the world of people who belong inside or the difficult world of reality outside.

In the year 2035, convict James Cole reluctantly volunteers to be sent back in time to discover the origin of a deadly virus that wiped out nearly all of the earth's population and forced the survivors into underground communities. But when Cole is mistakenly sent to 1990 instead of 1996, he's arrested and locked up in a mental hospital. There he meets psychiatrist Dr. Kathryn Railly and the son of a famous virus expert who may hold the key to the Army of the 12 Monkeys; thought to be responsible for unleashing the killer disease.

Psychiatrist Sam Foster has a new patient, Henry Letham, who claims to be suicidal. In trying to diagnose him, Sam visits Henry's prior therapist and also finds Henry's mother -- even though Henry has said that he murdered both of his parents. As reality starts to contradict fact, Sam spirals into an unstable mental state. Then he finds a clue as to how and when Henry may try to kill himself, and races to try to stop him.

A psychiatrist, whose client commits suicide, finds his family life disrupted after introducing her surviving brother to his wife and daughter.

Matthew, a young schizophrenic, finds himself out on the street when a slumlord tears down his apartment building. Soon, he finds himself in even more dire straits, when he is threatened by Little Leroy, a thug who is one of the tough denizens of the Fort Washington Shelter for Men. He reaches out to Jerry, a streetwise combat veteran, who takes Matthew under his wing as a son. The relationship between these two men grows as they attempt to conquer the numbing isolation of homelessness.

At the University of Chicago, a research team that includes brilliant student machinist Eddie Kasalivich experiences a breakthrough: a stable form of fusion that may lead to a waste-free energy source. However, a private company wants to exploit the technology, so Kasalivich and physicist Dr. Lily Sinclair are framed for murder, and the fusion device is stolen. On the run from the FBI, they must recover the technology and exonerate themselves.

A young man struggles to access sublimated childhood memories. He finds a technique that allows him to travel back into the past, to occupy his childhood body and change history. However, he soon finds that every change he makes has unexpected consequences.

A petty criminal fakes insanity to serve his sentence in a mental ward rather than prison. He soon finds himself as a leader to the other patients—and an enemy to the cruel, domineering nurse who runs the ward.

A mentally disturbed man takes residence in a halfway house. His mind gradually slips back into the realm created by his illness, where he replays a key part of his childhood.

Professor James Murray begins work compiling words for the first edition of the Oxford English Dictionary in the mid 19th century, and receives over 10,000 entries from a patient at Broadmoor Criminal Lunatic Asylum, Dr. William Minor.

Beth, Calvin, and their son Conrad are living in the aftermath of the death of the other son. Conrad is overcome by grief and misplaced guilt to the extent of a suicide attempt. He is in therapy. Beth had always preferred his brother and is having difficulty being supportive to Conrad. Calvin is trapped between the two trying to hold the family together.

At the end of WWII, Jimmy Picard, a Native American Blackfoot who fought in France, suffers from unexplainable symptoms and is admitted to a military hospital. When doctors suspect schizophrenia, an eccentric psychoanalyst takes up the case and starts a conversation with the veteran.

An undercover cop in a not-too-distant future becomes involved with a dangerous new drug and begins to lose his own identity as a result.

William Keane is barely able to cope. It has been six months since his six-year-old daughter was abducted from New York City’s Port Authority Bus Terminal while traveling with him. Repeatedly drawn to the site of the abduction, Keane wanders the bus station, compulsively replaying the events of that fateful day, as if hoping to change the outcome.

A young woman with psychokinetic powers breaks out of a Louisiana asylum and makes her way to New Orleans, where she falls into the city’s netherworld of misfits and miscreants.

After narrowly escaping a bizarre accident, a troubled teenager is plagued by visions of a large bunny rabbit that manipulates him to commit a series of crimes.

After a botched bank robbery lands his younger brother in prison, Connie Nikas embarks on a twisted odyssey through New York City's underworld to get his brother Nick out of jail.

In a dystopian future, insurance fraud investigator William Gold arrives in Shanghai to investigate a forgery ring for "papelles", futuristic passports that record people's identities and genetics. Gold falls for Maria Gonzalez, the woman in charge of the forgeries. After a passionate affair, Gold returns home, having named a coworker as the culprit. But when one of Gonzalez's customers is found dead, Gold is sent back to Shanghai to complete the investigation.

Jordan Turner is an experienced 911 operator but when she makes an error in judgment and a call ends badly, Jordan is rattled and unsure if she can continue. But when teenager Casey Welson is abducted in the back of a man's car and calls 911, Jordan is the one called upon to use all of her experience, insights and quick thinking to help Casey escape, and not just to save her, but to make sure the man is brought to justice.